LEVITRA Famacéutica Form and Formulation Each tablet contains: Vardenafil hydrochloride trihydrate equivalent to 5, 10 and 20 mg of vardenafil Excipient c.b.p. 1 tablet. Dosage and administration Usual recommended dose: The recommended starting dose is one tablet of 10 mg LEVITRA ® administered when necessary, about 25 to 60 minutes before the start of sexual activity. INDICATIONS: Treatment of erectile dysfunction (inability to achieve or maintain a penile erection adequate for satisfactory sexual performance yield). Pharmacokinetics: Pharmacokinetics Vardenafil is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations 0.5 to 2 hours after oral administration. The mean absolute oral bioavailability is 15% (range: 8.1 to 25.2%). There is no clinically relevant interaction with food. When vardenafil is administered with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 1 hour and a mean reduction in Cmax of 20%. Vardenafil is metabolised predominantly by hepatic enzymes via CYP3A4, with some contribution from CYP3A5 and CYP2C9 isoforms. After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of the administered dose) and to a lesser extent in the urine (approximately 2-6% of the administered dose) with a terminal half-life about 4 to 5 hours. In humans increased circulating metabolite (M1) showing a selectivity profile for phosphodiesterase-5 similar to vardenafil and inhibitory potency in vitro for phosphodiesterase-5 of approximately 28% compared to vardenafil is formed, resulting in a contribution to the effectiveness of about 7%. The metabolite is subject to other metabolic process, with a terminal half life of approximately 4-5 hours. The hepatic clearance of vardenafil is not significantly reduced in elderly patients. The pharmacokinetics of vardenafil does not change significantly in patients with renal impairment (including creatinine clearance <30 ml / min; severe renal insufficiency). In patients with hepatic impairment Child-Pugh classification A and B; elimination of vardenafil is reduced in proportion to the degree of hepatic dysfunction. No dose adjustment is required in patients with mild hepatic impairment (Child-Pugh A). In patients with mild hepatic impairment (Child-Pugh A), the AUC and Cmax of vardenafil increased 1.2 times, ABC 17% and Cmax by 22%, compared with healthy controls subjects. In patients with moderate hepatic impairment (Child-Pugh B), the AUC of vardenafil increased 2.6 times (160%) and Cmax increased 2.3 times (130%) compared with healthy controls subjects. Not studied the pharmacokinetics of vardenafil in patients with severe hepatic impairment (Child-Pugh C). pharmacodynamics Pharmacotherapeutic group: Medicinal Product used for erectile dysfunction. Penile erection is a hemodynamic process based on the relaxation of smooth muscles of the corpora cavernosa and arterioles. During sexual stimulation, from nerve ends in the corpus cavernosum nitric oxide (NO), which activates the enzyme guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum is released. This, in turn, causes relaxation of vascular smooth muscle, increasing blood entering the penis vessels. The level of cGMP by synthesis via guanylate cyclase index first, and the rate of degradation via hydrolysis by phosphodiesterases (PDEs), is regulated by the other. The predominant PDE in the human corpus cavernosum is phosphodiesterase type 5 PDE-5, specific for cGMP. Through the inhibition of PDE-5, responsible for degradation of cGMP in the corpus cavernosum enzyme, vardenafil significantly increases the effect of endogenous NO to be released locally in the corpus cavernosum during sexual stimulation. Inhibition of PDE-5 by vardenafil leads to increased levels of cGMP in the corpus cavernosum and arteries, resulting in smooth muscle relaxation and concomitantly increased blood inflow into the corpora cavernosa. Thus, vardenafil potentiates the natural response to sexual stimulation. Clinical Studies: Vardenafil demonstrated clinically and statistically significant improvement in erectile function compared with placebo in all major efficacy studies, including special populations. In all global clinical studies vardenafil administered over 17,000 men with erectile dysfunction, many of which have multiple other conditions. Over 2,500 patients were treated with vardenafil for 6 months or more. Of these, 900 patients were treated for one year or more. In a randomized, double-blind, placebo-controlled, fixed-dose, based on a question of overall assessment (SGA), vardenafil at doses of 5, 10 and 20 mg, improved erections in 65, 80 and 85% of patients, respectively, at 6 months, compared with 28% of placebo. In the combined data of the main efficacy studies, including special populations, the percentage of patients who had successful penetration with her first dose of treatment was 68% with 10 mg of vardenafil, 70% with 20 and 37 mg of vardenafil % with placebo. Among patients who had successful penetration with her first dose, patients treated with 10 and 20 mg of vardenafil satisfactorily answered on average 86 and 90%, respectively, subsequent attempts during the study period of 3 months. Vardenafil was effective in patients, irrespective of baseline severity, etiology, organic, psychogenic and mixed, duration of ED, ethnicity and age, as determined in the subgroup analyzes.
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There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.
What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.
What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.
Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.
Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. www.mexicanpharm.com Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.
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