Tempra Forte Acetaminophen 650 mg 24 tabs

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Tempra forte

Tempra forte is an anilide group medication that has analgesic, anti-inflammatory, antipyretic effects.  Refers to non-narcotic analgesics.  The chemical formula is C8H9NO2.


Appointment Tempra forte

 Tempra forte is prescribed in the following conditions:

 • Headache and toothache;

 • Migraine;

 • Pain after injury;

 • Algodismenorea;

 • Myalgia;

 • arthralgia;

 • Influenza, which is accompanied by muscle and headache, fever;

 • Inflammatory processes;

 • Neuralgic pains;

 • Osteoarthritis;

 • Postoperative pain;

 • Oncological pain.



Absorption - high, maximum concentration (Cmax) 5–20 μg / ml, time to reach maximum concentration (TCmax) 0.5–2 hours.  It binds to plasma proteins by 15%.  Penetrates through the blood-brain barrier.  During lactation, less than 1% of the active substance passes into breast milk.

About 97% of the medication is metabolized in the liver: 80% undergoes a conjugation reaction with glucuronic acid and sulfates to form inactive metabolites (glucuronide and paracetamol sulfate), 17% undergoes hydroxylation with the formation of eight active metabolites that conjugate with glutathione to form already inactive metabolites.  With a lack of glutathione, these metabolites can block the hepatocyte enzyme systems and cause their necrosis.  The isoenzyme of CYP2E1 is also involved in the metabolism of the medication.

The elimination half-life (T½) is 1–4 hours.  It is excreted by the kidneys in the form of metabolites, about 3% - unchanged.  In elderly patients, the clearance of the medication decreases and T½ increases.



 It is not recommended to take Tempra forte in the following cases:

 • Individual sensitivity to the components of the medication;

 • Together with alcohol;

 • Children up to 1 month.

With extreme caution Tempra forte should be used in cases of renal or hepatic insufficiency, benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver damage, alcoholism, pregnancy, lactation, old age, early infancy (about 1 to 3 months), glucose-6-phosphate dehydrogenase deficiency.


Side effects

Tempra forte may cause the following side effects:

 1. From the skin: itching, rash on the skin and mucous membranes (usually erythematous, urticaria), angioedema, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

 2. From the side of the central nervous system (usually develops when taking high doses): dizziness, psychomotor agitation and disorientation.

 3. From the digestive system: nausea, epigastric pain, increased activity of "liver" enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).

 4. From the endocrine system: hypoglycemia, up to hypoglycemic coma.

 5. Hematopoietic organs: anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency).  With prolonged use in large doses - aplastic anemia, thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, neutropenia.

 6. From the urinary system: (when taking large doses) - nephrotoxicity (renal colic, interstitial nephritis, papillary necrosis).



Symptoms (an acute overdose develops 6-14 hours after taking paracetamol, chronic 2-4 days after the dose is taken) of an acute overdose: gastrointestinal tract dysfunction (diarrhea, decreased appetite, nausea and vomiting. Overdose cause discomfort and pain in  abdomen, increased sweating.

Symptoms of a chronic overdose: a hepatotoxic effect develops, characterized by general symptoms (pain, weakness, adynamia, increased sweating) and specific, characterizing liver damage.  As a result, hepatonecrosis may develop.  The hepatotoxic effect of paracetamol can be complicated by the development of hepatic encephalopathy (impaired thinking, CNS depression, stupor), convulsions, respiratory depression, coma, cerebral edema, hypocoagulation, the development of DIC, hypoglycemia, metabolic acidosis, arrhythmia, collapse.  Rarely, liver dysfunction develops at lightning speed and can be complicated by renal failure (renal tubular necrosis).

Treatment: administration of SH-group donors and precursors of glutathione-methionine synthesis 8-9 hours after an overdose and N-acetylcysteine ​​12 hours later.The need for additional therapeutic measures (further administration of methionine, iv administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.


Dosage and administration

Tempra forte is taken orally, drinking a tablet with plenty of water 1-2 hours after a meal.

For adults with a body weight of more than 40 kg, a single dose is 1 tablet (650 mg).  The maximum single dose is 1 g.  The medication is prescribed up to 3-4 times a day.  The maximum daily dose is 4g.

The interval between doses should be increased in patients with renal and hepatic insufficiency, in the elderly.

The maximum duration of treatment without consulting a doctor is 3 days (when taken as an antipyretic medication) and 5 days (as an analgesic).



Treatment reduces the effectiveness of uricosuric medications.  Concomitant use in high doses increases the effect of anticoagulant medications (a decrease in the synthesis of procoagulant factors in the liver).

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic medications increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose.

Prolonged use of barbiturates reduces the effectiveness of the medication.

Ethanol contributes to the development of acute pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxicity.

Prolonged sharing and other NSAIDs increases the risk of developing “analgesic” nephropathy and renal papillary necrosis, the onset of end-stage renal failure.

Diflunisal increases plasma concentration by 50% - the risk of hepatotoxicity.

Myelotoxic medications increase the manifestations of hematotoxicity of the medication.



 Tempra Forte is from the family of acetaminophen (paracetamol), a secure and efficient analgesic and antipyretic. It isn’t a salicylate neither does it contains caffeine or phenacetin. Tempra Forte has no result on prothrombin point. It is predominantly helpful for administration in subjects who do not endure aspirin well since it is less probable to induce gastrointestinal disorders.

It is helpful for dropping fever and for the transitory respite of insignificant pains, aches and uneasiness linked with the flu or common colds, vaccinations or inoculations. It is also helpful in decreasing pain because of adenoidectomy and tonsillectomy.

Tempra forte may also be administered for other ailments not mentioned above.


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Shipping & Returns

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IMPORTANT: If you need to make some changes in regards an existing order, contact us within 24 hours, otherwise, Mexican Pharm is not liable due to errors on customer’s information or products presentation. 


Shipping Methods.

To ensure the delivery of your order we handle EXPRESS SHIPPING only. Signature is required.
Tracking numbers for all orders will be sent with instructions once shipped.


How long does it take to ship the drugs to my home or office?

  • Express USA time frame: 10-21 business days.   ($24.95 USD Signature required)
  • Express World Wide time frame: 15-30 business days.  ($39.95 USD Signature required)


*Due to unexpected Postal Service changes, one of the shipping methods above could be temporarily disabled.

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Express Shipping.
We offer Mex Post Express Shipping as an option. This option costs from $24.95 depending on the quantity of medications in your order (up to 9 medications). This option requires a customer signature on delivery. For all other locations Express Shipping is $39.95. All packages are shipped in plain packaging to guarantee your privacy. All packages are sent by parcel express mail from Mexico. Some parcels require a signature upon delivery at our discretion. There are no other handling fees, drug dispensing fees, or Mexican customs charges. If two or more people are ordering their prescription drugs from the same address at the same time, you will be billed for only one shipping charge from our Mexico pharmacy, up to our maximum order quantities limited by customs to 90 day supply. We are able to provide a tracking number on your express shipping parcels. If after 30 business days your order has not arrived, first check with your local postal office to ensure that your package is not being held for pick-up. If you still have problems, please contact us by email and we will attempt to assist you.

Notice Left
If no one is at home at the time of delivery, the status of you order on the Postal System will be updated to “Notice Left” which means USPS attempted to deliver your item and a notice was left because an authorized recipient was not available. You may arrange redelivery by visiting or calling 800-ASK-USPS, or may pick up the item at the Post Office indicated on the notice. If this item is unclaimed after five days then it will be returned to the sender. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

Note that on Holidays season, the Mexican Postal, USA and other countries will be extra busy; therefore a delay is expected in packages shipped during this season. You will need to consider as well the Mexican holidays. We appreciate your understanding, our customer service will be happy to assist you and available to inform you the latest status on your existing order shipped, you can always contact us at Toll Free number or email address.

Order Cancellation
Due to our policy of same day payment processing, ORDERS CANNOT BE CANCELLED.

Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. In case your package is returned due to no one was available to sign for it. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

How to find the online pharmacy drug you need.
There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.

What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.

What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.

Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.

Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. www.mexicanpharm.com Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.



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When contacting a service center with you, you must take:

  • original warranty card;
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The warranty is provided for a period of 2 weeks to 99 months. Please check the completeness and absence of defects in the goods upon receipt.


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