Supradol Ketorolac tromethamine 10 mg 40 Tabs

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Supradol is a medication that has a pronounced analgesic effect, moderate anti-inflammatory and antipyretic.  The active substance is ketorolac tromethamine.

Prescribing Supradol

 Supradol is prescribed for intense and moderate pain syndrome:

 • for oncological pain

 • neurological pain

 • for injuries

 • in the postoperative period


Supradol acts on COX1 and COX2, suppressing the biosynthesis of prostaglandidae - modulators of pain sensitivity, thermoregulation and inflammation.  The medication does not affect opioid receptors, does not inhibit respiration, does not cause medication dependence, does not have a sedative and anxiolytic effect. After oral administration, the onset of analgesic action is noted after 60 minutes, the maximum effect is achieved after 1-2 hours and 2-3 hours.


When administered, Supradol is well absorbed in the gastrointestinal tract - the maximum plasma concentration (Cmax) (0.7-1.1 μg / ml) is achieved 40 minutes after a fasting dose of 10 mg.  Foods rich in fats reduce the maximum concentration of the medication in the blood and delay its achievement by 1 hour.  99% of the medication binds to plasma proteins and with hypoalbuminemia, the amount of free substance in the blood increases.  Bioavailability is 80-100%.  The time to reach equilibrium concentration (Css) when administered orally is 24 hours when administered 4 times a day (higher than sub-therapeutic) and is after oral administration of 10 mg - 0.39-0.79 μg / ml.  The volume of distribution is 0.15-0.33 l / kg.  In patients with renal failure, the volume of distribution of the medication may increase by 2 times, and the volume of distribution of its R-enantiomer - by 20%.  Penetrates into breast milk: when the mother takes 10 mg of Supradol Cmax in milk, it is reached 2 hours after the first dose and is 7.3 ng / ml, 2 hours after the second dose of Supradol (when using the medication 4 times a day) -  7.9 ng / ml.

More than 50% of the administered dose is metabolized in the liver with the formation of pharmacologically inactive metabolites.  The main metabolites are glucuronides. It excreted by the kidneys and p-hydroxyketorolac.  It is excreted by 91% by the kidneys and 6% through the intestines.  Half-life (T1 / 2) in patients with normal renal function is on average 5.3 hours. T1 / 2 increases in elderly patients and shortens in young patients.  Liver function has no effect on T1 / 2.  In patients with impaired renal function with a creatinine concentration in plasma of 19-50 mg / l (168-442 mmol / l).  T1 / 2 - 10.3-10.8 hours, with more severe renal failure - more than 13.6 hours.It is not excreted by hemodialysis.


Supradol is not used to treat chronic pain.  The medication has contraindications:

 • hypersensitivity to ketorolac or other non-steroidal anti-inflammatory medications (NSAIDs);

 • intolerance to acetylsalicylic acid;

 • bronchial asthma, recurrent polyps of the nose and sinuses;

 • any allergic reactions caused by a history of NSAIDs;

 • hyperkalemia;

 • hypovolemia;

 • ulcer during exacerbation;

 • any inflammation of the digestive tract;

 • renal or liver failure;

 • hypocoagulation;

 • risk of bleeding;

 • the period after coronary artery bypass grafting;

 • ischemic, hemorrhagic stroke;

 • lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

 • children and adolescents under 16 years of age (effectiveness and safety have not been established);

 • pregnancy;

 • lactation period.

Dosage and administration

A single dose of Supradol is 10 mg.  Depending on the intensity of the pain, up to 4 medications per day are allowed.  The maximum daily dose is 40 mg.  You should not take Supradol  for more than 5 days.


In case of an overdose, the following symptoms may be observed: abdominal pain, nausea, vomiting, the appearance of peptic ulcers of the stomach or erosive gastritis, impaired renal function, metabolic acidosis.

Treatment is carried out by gastric lavage, the introduction of adsorbents (activated charcoal) and symptomatic therapy (maintaining vital functions in the body).  Not sufficiently excreted by dialysis.

Side effects

Often - more than 3%, less often - 1-3%, rarely - less than 1%.

From the digestive system: gastralgia, diarrhea;  less often - stomatitis, flatulence, constipation, vomiting, a feeling of fullness of the stomach;  rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the stool or melena, vomiting with blood, nausea, heartburn, etc.)  , cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.

From the urinary system: rarely - acute renal failure, lower back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema  renal origin.

From the sensory organs: rarely - hearing loss, tinnitus, visual impairment (including blurred visual perception).From the respiratory system: rarely - bronchospasm or dyspnea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, shortness of breath).

From the side of the central nervous system: often - headache, dizziness, drowsiness, rarely - aseptic meningitis (fever, severe headache, cramps, stiff muscles of the neck and / or back), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis.

From the cardiovascular system: increased blood pressure, pulmonary edema, loss of consciousness.

From the hemopoietic organs: anemia, leukopenia, eosinophilia.

On the part of the hemostatic system: rarely - bleeding from a postoperative wound, nosebleeds, rectal bleeding.

On the part of the skin: less often - a skin rash (including maculopapullous rash), purpura, rarely - exfoliative dermatitis (fever with or without chills, flushing, tightening or peeling of the skin, swelling and / or tenderness of the tonsils), urticaria, malignant exudative  (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

Local reactions: less often - burning or pain at the injection site.

Allergic reactions: rare - anaphylaxis or anaphylactoid reactions (discoloration of the face, skin rash, urticaria, itchy skin, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest, wheezing).

Other: often - edema (face, legs, ankles, fingers, feet, weight gain);  less often - increased sweating, rare - swelling of the tongue, fever.


On the off chance that its not greatly inconvenience guide your specialist before taking any arrangement. Supradol 10mg 30 Tabs Generic Name: Ketorolac Trometamol Non-sedative torment soothing. SUPRADOL ® tablets, sublingual tablets and mixture course of action is demonstrated for the treatment of extraordinary torment in the short term. SUPRADOL ® Gel, topically associated moderating agony soothing for the treatment of muscle misery, joint and post-traumatic. It is convincing in the treatment of fragile tissue wounds, for instance, sprains, strains, bursitis, tendinitis, epicondylitis, synovitis and osteoarthritis joints surface (finger, knee, lower l


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Shipping & Returns

 we are a Registered and Licensed Mexican pharmacy we assure you top quality medicines without the worry of your health care provider, employer or any other group finding out what rightfully is a private issue.

Did you know that your private medical file can be used against you to raise your insurance rates or in some cases and countries to lose your job? We take your privacy very seriously and by using these payment methods and the way in which we use them your bank does not directly get charged from our pharmacy. This way your medical needs stay as private as possible.

You will also receive a complete invoice in your email with payment totals and simple payment instructions toward the bottom of the email should you wish to pay at a later convenience.

IMPORTANT: If you need to make some changes in regards an existing order, contact us within 24 hours, otherwise, Mexican Pharm is not liable due to errors on customer’s information or products presentation. 


Shipping Methods.

To ensure the delivery of your order we handle EXPRESS SHIPPING only. Signature is required.
Tracking numbers for all orders will be sent with instructions once shipped.


How long does it take to ship the drugs to my home or office?

  • Express USA time frame: 10-21 business days.   ($24.95 USD Signature required)
  • Express World Wide time frame: 15-30 business days.  ($39.95 USD Signature required)


*Due to unexpected Postal Service changes, one of the shipping methods above could be temporarily disabled.

IMPORTANT: Please ensure your mail program is configured to accept email from sender, add our email to your non blocked email address so we may send invoices, order status and shipping confirmations. If you do not receive your invoice immediately after this, please check your spam filter and make necessary changes. 

We reply promptly to your enquiries and requests emails, but are too busy to repeatedly resend email that customers do not receive because our replies have been moved to a customers’ Spam, Junk or Bulk email folder.

Online pharmacy Medicines Mexico shipping terms and conditions.
Our team endeavors to process all orders and ship within 72 business hours. All credit card and electronic check payments for your mexicanpharm take 24 to 48 hours to be approved by our Payment Processor; upon verification your order will be processed. If there are any problems with your order, we will contact you, so please ensure the email address and phone number you provide is correct, and that any spam filtering software you use accepts email from

Express Shipping.
We offer Mex Post Express Shipping as an option. This option costs from $24.95 depending on the quantity of medications in your order (up to 9 medications). This option requires a customer signature on delivery. For all other locations Express Shipping is $39.95. All packages are shipped in plain packaging to guarantee your privacy. All packages are sent by parcel express mail from Mexico. Some parcels require a signature upon delivery at our discretion. There are no other handling fees, drug dispensing fees, or Mexican customs charges. If two or more people are ordering their prescription drugs from the same address at the same time, you will be billed for only one shipping charge from our Mexico pharmacy, up to our maximum order quantities limited by customs to 90 day supply. We are able to provide a tracking number on your express shipping parcels. If after 30 business days your order has not arrived, first check with your local postal office to ensure that your package is not being held for pick-up. If you still have problems, please contact us by email and we will attempt to assist you.

Notice Left
If no one is at home at the time of delivery, the status of you order on the Postal System will be updated to “Notice Left” which means USPS attempted to deliver your item and a notice was left because an authorized recipient was not available. You may arrange redelivery by visiting or calling 800-ASK-USPS, or may pick up the item at the Post Office indicated on the notice. If this item is unclaimed after five days then it will be returned to the sender. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

Note that on Holidays season, the Mexican Postal, USA and other countries will be extra busy; therefore a delay is expected in packages shipped during this season. You will need to consider as well the Mexican holidays. We appreciate your understanding, our customer service will be happy to assist you and available to inform you the latest status on your existing order shipped, you can always contact us at Toll Free number or email address.

Order Cancellation
Due to our policy of same day payment processing, ORDERS CANNOT BE CANCELLED.

Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. In case your package is returned due to no one was available to sign for it. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

How to find the online pharmacy drug you need.
There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.

What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.

What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.

Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.

Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.



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When contacting a service center with you, you must take:

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The warranty is provided for a period of 2 weeks to 99 months. Please check the completeness and absence of defects in the goods upon receipt.


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