Supradol Ketorolac tromethamine 10 mg 40 Tabs

Supradol Ketorolac tromethamine 10 mg 40 Tabs

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$78.38

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Supradol

Supradol is a medication that has a pronounced analgesic effect, moderate anti-inflammatory and antipyretic. The active substance is ketorolac tromethamine.

Prescribing Supradol

Supradol is prescribed for intense and moderate pain syndrome:

• for oncological pain

• neurological pain

• for injuries

• in the postoperative period

Pharmacodynamics

Supradol acts on COX1 and COX2, suppressing the biosynthesis of prostaglandidae - modulators of pain sensitivity, thermoregulation and inflammation. The medication does not affect opioid receptors, does not inhibit respiration, does not cause medication dependence, does not have a sedative and anxiolytic effect. After oral administration, the onset of analgesic action is noted after 60 minutes, the maximum effect is achieved after 1-2 hours and 2-3 hours.

Pharmacokinetics

When administered, Supradol is well absorbed in the gastrointestinal tract - the maximum plasma concentration (Cmax) (0.7-1.1 μg / ml) is achieved 40 minutes after a fasting dose of 10 mg. Foods rich in fats reduce the maximum concentration of the medication in the blood and delay its achievement by 1 hour. 99% of the medication binds to plasma proteins and with hypoalbuminemia, the amount of free substance in the blood increases. Bioavailability is 80-100%. The time to reach equilibrium concentration (Css) when administered orally is 24 hours when administered 4 times a day (higher than sub-therapeutic) and is after oral administration of 10 mg - 0.39-0.79 μg / ml. The volume of distribution is 0.15-0.33 l / kg. In patients with renal failure, the volume of distribution of the medication may increase by 2 times, and the volume of distribution of its R-enantiomer - by 20%. Penetrates into breast milk: when the mother takes 10 mg of Supradol Cmax in milk, it is reached 2 hours after the first dose and is 7.3 ng / ml, 2 hours after the second dose of Supradol (when using the medication 4 times a day) - 7.9 ng / ml.

More than 50% of the administered dose is metabolized in the liver with the formation of pharmacologically inactive metabolites. The main metabolites are glucuronides. It excreted by the kidneys and p-hydroxyketorolac. It is excreted by 91% by the kidneys and 6% through the intestines. Half-life (T1 / 2) in patients with normal renal function is on average 5.3 hours. T1 / 2 increases in elderly patients and shortens in young patients. Liver function has no effect on T1 / 2. In patients with impaired renal function with a creatinine concentration in plasma of 19-50 mg / l (168-442 mmol / l). T1 / 2 - 10.3-10.8 hours, with more severe renal failure - more than 13.6 hours.It is not excreted by hemodialysis.

Contraindications

Supradol is not used to treat chronic pain. The medication has contraindications:

• hypersensitivity to ketorolac or other non-steroidal anti-inflammatory medications (NSAIDs);

• intolerance to acetylsalicylic acid;

• bronchial asthma, recurrent polyps of the nose and sinuses;

• any allergic reactions caused by a history of NSAIDs;

• hyperkalemia;

• hypovolemia;

• ulcer during exacerbation;

• any inflammation of the digestive tract;

• renal or liver failure;

• hypocoagulation;

• risk of bleeding;

• the period after coronary artery bypass grafting;

• ischemic, hemorrhagic stroke;

• lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

• children and adolescents under 16 years of age (effectiveness and safety have not been established);

• pregnancy;

• lactation period.

Dosage and administration

A single dose of Supradol is 10 mg. Depending on the intensity of the pain, up to 4 medications per day are allowed. The maximum daily dose is 40 mg. You should not take Supradol for more than 5 days.

Overdose

In case of an overdose, the following symptoms may be observed: abdominal pain, nausea, vomiting, the appearance of peptic ulcers of the stomach or erosive gastritis, impaired renal function, metabolic acidosis.

Treatment is carried out by gastric lavage, the introduction of adsorbents (activated charcoal) and symptomatic therapy (maintaining vital functions in the body). Not sufficiently excreted by dialysis.

Side effects

Often - more than 3%, less often - 1-3%, rarely - less than 1%.

From the digestive system: gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, a feeling of fullness of the stomach; rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the stool or melena, vomiting with blood, nausea, heartburn, etc.) , cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.

From the urinary system: rarely - acute renal failure, lower back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema renal origin.

From the sensory organs: rarely - hearing loss, tinnitus, visual impairment (including blurred visual perception).From the respiratory system: rarely - bronchospasm or dyspnea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, shortness of breath).

From the side of the central nervous system: often - headache, dizziness, drowsiness, rarely - aseptic meningitis (fever, severe headache, cramps, stiff muscles of the neck and / or back), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis.

From the cardiovascular system: increased blood pressure, pulmonary edema, loss of consciousness.

From the hemopoietic organs: anemia, leukopenia, eosinophilia.

On the part of the hemostatic system: rarely - bleeding from a postoperative wound, nosebleeds, rectal bleeding.

On the part of the skin: less often - a skin rash (including maculopapullous rash), purpura, rarely - exfoliative dermatitis (fever with or without chills, flushing, tightening or peeling of the skin, swelling and / or tenderness of the tonsils), urticaria, malignant exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

Local reactions: less often - burning or pain at the injection site.

Allergic reactions: rare - anaphylaxis or anaphylactoid reactions (discoloration of the face, skin rash, urticaria, itchy skin, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest, wheezing).

Other: often - edema (face, legs, ankles, fingers, feet, weight gain); less often - increased sweating, rare - swelling of the tongue, fever.

On the off chance that its not greatly inconvenience guide your specialist before taking any arrangement. Supradol 10mg 30 Tabs Generic Name: Ketorolac Trometamol Non-sedative torment soothing. SUPRADOL ® tablets, sublingual tablets and mixture course of action is demonstrated for the treatment of extraordinary torment in the short term. SUPRADOL ® Gel, topically associated moderating agony soothing for the treatment of muscle misery, joint and post-traumatic. It is convincing in the treatment of fragile tissue wounds, for instance, sprains, strains, bursitis, tendinitis, epicondylitis, synovitis and osteoarthritis joints surface (finger, knee, lower l

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What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.

What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.

Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.

Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. www.mexicanpharm.com Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.

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